Sci. STKE, 23 September 2003
INTEGRINS Real-Time Signaling Both Ways
Integrins are heterodimeric membrane proteins that signal bidirectionally across the cell surface. Their activation is associated with conformational changes in their extracellular domains, but interaction between the subunit intracellular domains is also likely to be important for regulating activation and signaling. Using fluorescence resonance energy transfer in living cells, Kim et al. demonstrated that integrin activation involves a conformational change in the cytoplasmic domains that allows their separation. Signals transmitted in either direction--from the cell outward, or from outside the cell inward--appeared to be coupled to this mechanism.
Citation: Real-Time Signaling Both Ways. Sci. STKE 2003, tw370 (2003).
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