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Sci. STKE, 30 September 2003
Vol. 2003, Issue 202, p. pe41
[DOI: 10.1126/stke.2003.202.pe41]


Does Selection Mold Molecular Networks?

Andreas Wagner*

University of New Mexico, Department of Biology, 167A Castetter Hall, Albuquerque, NM 817131-1091, USA.

Abstract: The dissection of molecular networks vital to cellular life can provide important hints about optimal network design principles. However, these hints can become conclusive only if one can determine that natural selection has molded a network's structure. I illustrate the importance of thorough studies of network evolution with two recent examples, one from genome-scale networks, the other from small transcriptional regulation circuits.

*Contact information. Telephone, 505-277-2021; fax, 505-277-0304; e-mail, wagnera{at}

Citation: A. Wagner, Does Selection Mold Molecular Networks? Sci. STKE 2003, pe41 (2003).

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