Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 30 September 2003
Vol. 2003, Issue 202, p. pe41
[DOI: 10.1126/stke.2003.202.pe41]

PERSPECTIVES

Does Selection Mold Molecular Networks?

Andreas Wagner*

University of New Mexico, Department of Biology, 167A Castetter Hall, Albuquerque, NM 817131-1091, USA.

Abstract: The dissection of molecular networks vital to cellular life can provide important hints about optimal network design principles. However, these hints can become conclusive only if one can determine that natural selection has molded a network's structure. I illustrate the importance of thorough studies of network evolution with two recent examples, one from genome-scale networks, the other from small transcriptional regulation circuits.

*Contact information. Telephone, 505-277-2021; fax, 505-277-0304; e-mail, wagnera{at}unm.edu

Citation: A. Wagner, Does Selection Mold Molecular Networks? Sci. STKE 2003, pe41 (2003).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genomes, phylogeny, and evolutionary systems biology.
M. Medina (2005)
PNAS 102, 6630-6635
   Abstract »    Full Text »    PDF »
Biological Networks: The Tinkerer as an Engineer.
U. Alon (2003)
Science 301, 1866-1867
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882