Sci. STKE, 14 October 2003
CELL CYCLE Keeping in Time
A functional pathway that connects the cell cycle and the circadian clock has long been suspected. Matsuo et al. (see the Perspective by Schibler) have now identified a molecular link between these two major control systems that could explain how proliferating cells use information from the circadian clock to regulate the timing of cell division. In murine regenerating liver, the expression of three key regulators of mitosis was controlled in a diurnal fashion. One of these factors, called WEE1, was directly regulated by two transcription factors that are core components of the mammalian circadian clock.
Citation: Keeping in Time. Sci. STKE 2003, tw402 (2003).
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