Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 14 October 2003
Vol. 2003, Issue 204, p. tw406
[DOI: 10.1126/stke.2003.204.tw406]


NEUROBIOLOGY Knowing When to Branch

Neuronal axons form branches to establish precise connections with their targets, but branch control is not well understood. Colavita and Tessier-Lavigne have identified a subset of neurons in Caenorhabditis elegans that require a membrane protein called BAM-2 (branching abnormal) to stop formation of branches and to stabilize their termination. Loss of BAM-2 allowed branches to overshoot their normal termination sites. BAM-2 shows sequence similarity to neurexins that are thought to control the stability of neuronal synapses.

A. Colavita, M. Tessier-Lavigne, A neurexin-related protein, BAM-2, terminates axonal branches in C. elegans. Science 302, 293 (2003). [Abstract] [Full Text]

Citation: Knowing When to Branch. Sci. STKE 2003, tw406 (2003).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882