Sci. STKE, 14 October 2003
NEUROBIOLOGY Knowing When to Branch
Neuronal axons form branches to establish precise connections with their targets, but branch control is not well understood. Colavita and Tessier-Lavigne have identified a subset of neurons in Caenorhabditis elegans that require a membrane protein called BAM-2 (branching abnormal) to stop formation of branches and to stabilize their termination. Loss of BAM-2 allowed branches to overshoot their normal termination sites. BAM-2 shows sequence similarity to neurexins that are thought to control the stability of neuronal synapses.
Citation: Knowing When to Branch. Sci. STKE 2003, tw406 (2003).
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