Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 21 October 2003
Vol. 2003, Issue 205, p. pe45
[DOI: 10.1126/stke.2003.205.pe45]

PERSPECTIVES

Is Reelin the Answer to Synapse Elimination at the Neuromuscular Junction?

Ben Chih and Peter Scheiffele*

Department of Physiology and Cellular Biophysics, and Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

Abstract: The formation of mature neuronal circuits during development involves elimination of a large number of synapses by activity-dependent processes. A recent study suggests that synapse elimination at the neuromuscular junction is impaired in reeler mutant mice, which are lacking the extracellular matrix protein Reelin. In this process, Reelin acts through an unexpected, proteolytic mechanism that is independent of Disabled 1, a cytoplasmic factor that mediates Reelin signaling in the central nervous system. This Perspective discusses possible models for Reelin function in the framework of activity-dependent synapse elimination at the neuromuscular junction.

*Corresponding author. E-mail: ps2018{at}columbia.edu

Citation: B. Chih, P. Scheiffele, Is Reelin the Answer to Synapse Elimination at the Neuromuscular Junction? Sci. STKE 2003, pe45 (2003).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comment on "Reelin Promotes Peripheral Synapse Elimination and Maturation".
C. Bidoia, T. Misgeld, E. Weinzierl, M. Buffelli, G. Feng, A. Cangiano, J. W. Lichtman, and J. R. Sanes (2004)
Science 303, 1977b
   Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882