Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 28 October 2003
Vol. 2003, Issue 206, p. tw424
[DOI: 10.1126/stke.2003.206.tw424]

EDITORS' CHOICE

IMMUNOLOGY Destroyed in Transit

Despite the huge global rise in tuberculosis, protective immunity to the causative pathogen, Mycobacterium tuberculosis (Mtb), is measurable in most infected individuals. Critical in mediating this is the cytokine interferon-{gamma}, which activates various immune-response genes, of which nitric oxide synthase 2 (NOS2) is considered pivotal. MacMicking et al. identified a protein, LRG-47, that can mediate protection from Mtb infection independently of NOS2. Macrophages from mice lacking LRG-47 produced bacteria-laden phagosomes that could not fuse with lysosomes and thus impeded the normal cellular pathway for destroying intracellular bacteria.

J. D. MacMicking, G. A. Taylor, J. D. McKinney, Immune control of tuberculosis by IFN-{gamma}-inducible LRG-47. Science 302, 654-659 (2003). [Abstract] [Full Text]

Citation: Destroyed in Transit. Sci. STKE 2003, tw424 (2003).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882