Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 4 November 2003
Vol. 2003, Issue 207, p. tw432
[DOI: 10.1126/stke.2003.207.tw432]


IMMUNOLOGY Organ Transplantation: Extending a Brief Encounter

The need for improved specificity and lower toxicity in immune-suppressive drugs for organ transplantation has focused attention on the intracellular signaling pathways that regulate the immune responses of lymphocytes. Among these, the Janus kinase 3 (JAK3) has particular potential, because it mediates signals by several key cytokines, which each utilize a common gamma chain. Changelian et al. developed a highly selective, low-molecular-weight inhibitor of JAK3 that significantly extended organ allograft survival in primate and mouse organ transplant models after oral administration.

P. S. Changelian, M. E. Flanagan, D. J. Ball, C. R. Kent, K. S. Magnuson, W. H. Martin, B. J. Rizzuti, P. S. Sawyer, B. D. Perry, W. H. Brissette, S. P. McCurdy, E. M. Kudlacz, M. J. Conklyn, E. A. Elliott, E. R. Koslov, M. B. Fisher, T. J. Strelevitz, K. Yoon, D. A. Whipple, J. Sun, M. J. Munchhof, J. L. Doty, J. M. Casavant, T. A. Blumenkopf, M. Hines, M. F. Brown, B. M. Lillie, C. Subramanyam, C. Shang-Poa, A. J. Milici, G. E. Beckius, J. D. Moyer, C. Su, T. G. Woodworth, A. S. Gaweco, C. R. Beals, B. H. Littman, D. A. Fisher, J. F. Smith, P. Zagouras, H. A. Magna, M. J. Saltarelli, K. S. Johnson, L. F. Nelms, S. G. Des Etages, L. S. Hayes, T. T. Kawabata, D. Finco-Kent, D. L. Baker, M. Larson, M.-S. Si, R. Paniagua, J. Higgins, B. Holm, B. Reitz, Y.-J. Zhou, R. E. Morris, J. J. O'Shea, D. C. Borie, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 302, 875-878 (2003). [Abstract] [Full Text]

Citation: Organ Transplantation: Extending a Brief Encounter. Sci. STKE 2003, tw432 (2003).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882