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Sci. STKE, 18 November 2003
Vol. 2003, Issue 209, p. tw451
[DOI: 10.1126/stke.2092003TW451]

EDITORS' CHOICE

MOLECULAR SCAFFOLDS Nutrient Sensing and Gene Expression

Prefoldins belong to a family of small-molecular-weight proteins that act as molecular chaperones. Gstaiger et al. describe an unusually large member of this family, URI, that forms a large (>1 megadalton) complex with other small-molecular-weight prefoldins and a subunit shared by all three RNA polymerases. In yeast and human cells, URI is a target of nutrient signaling and participates in the control of nutrient-sensitive gene expression. Thus, URI may act as a molecular scaffold for a signaling pathway that coordinates nutrient availability with gene expression.

M. Gstaiger, B. Luke, D. Hess, E. J. Oakeley, C. Wirbelauer, M. Blondel, M. Vigneron, M. Peter, W. Krek, Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science 302, 1208-1212 (2003). [Abstract] [Full Text]

Citation: Nutrient Sensing and Gene Expression. Sci. STKE 2003, tw451 (2003).

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