Sci. STKE, 18 November 2003
NEUROBIOLOGY RNA Binding Proteins and the Control of Motor Activity
RNA binding proteins can play important roles in gene regulation and are also associated with a large number of human diseases. Identifying the sets of RNAs to which these proteins bind is critical to understanding their normal functions and roles in disease. Nova is a tissue-specific splicing factor involved in the disease paraneoplastic opsoclonus myoclonus ataxia (POMA), in which patients cannot inhibit movement and suffer uncontrollable shaking. Ule et al. developed an ultraviolet cross-linking and immunoprecipitation method to purify Nova-RNA complexes. Nova regulates a set of RNA targets that code for proteins involved in neuronal inhibition or that function at the synapse, consistent with POMA's being a disorder of motor inhibition.
Citation: RNA Binding Proteins and the Control of Motor Activity. Sci. STKE 2003, tw452 (2003).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882