Sci. STKE, 25 November 2003
NEUROBIOLOGY From Electrical Activity to Dendritic Spine Morphology
The activity-dependent remodeling of synapses that involves new gene expression is believed to be important for long-lasting forms of synaptic modification. Synaptic remodeling after plasticity induction involves the dismantling and reorganization of key cytoskeletal and scaffolding protein complexes. Pak and Sheng (see the Perspective by Meyer and Brose) investigated an important element of the signaling cascade that couples electrical activity to changes in dendritic spine morphology. An activity-inducible kinase, SNK, moves to synaptic spines and causes the phosphorylation and subsequent degradation of SPAR, a key protein in the postsynaptic density. This loss of SPAR then leads to the dismantling of dendritic spines.
Citation: From Electrical Activity to Dendritic Spine Morphology. Sci. STKE 2003, tw458 (2003).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882