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Sci. STKE, 2 December 2003
Vol. 2003, Issue 211, p. tw468
[DOI: 10.1126/stke.2112003tw468]

EDITORS' CHOICE

IMMUNOLOGY Controlling Immunological Signaling

Activation and nuclear translocation of the immune-response transcription factor nuclear factor-{kappa}B (NF-{kappa}B) depends on signals that emanate from a variety of cell-surface receptors. Two membrane-proximal caspase-recruitment proteins, CARMA1 and Bcl10, form part of the chain of signaling events, but other critical remaining steps in the pathway have yet to be established. Ruefli-Brasse et al. (see the Perspective by Yu and Lenardo) show that the caspase-like protein, paracaspase, is essential for lymphocyte function and acts downstream of CARMA1 and Bcl10. Impaired paracaspase-dependent activation of the kinase complex that normally facilitates NF-{kappa}B activation caused T and B cells from paracaspase-deficient mice to respond poorly to receptor signals.

A. A. Ruefli-Brasse, D. M. French, V. M. Dixit, Regulation of NF-{kappa}B-dependent lymphocyte activation and development by paracaspase. Science 302, 1581-1584 (2003). [Abstract] [Full Text]

L. Yu, M. J. Lenardo, Paracaspase connection. Science 302, 1515-1516 (2003). [Abstract] [Full Text]

Citation: Controlling Immunological Signaling. Sci. STKE 2003, tw468 (2003).


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