Sci. STKE, 2 December 2003
IMMUNOLOGY Controlling Immunological Signaling
Activation and nuclear translocation of the immune-response transcription factor nuclear factor-B (NF-B) depends on signals that emanate from a variety of cell-surface receptors. Two membrane-proximal caspase-recruitment proteins, CARMA1 and Bcl10, form part of the chain of signaling events, but other critical remaining steps in the pathway have yet to be established. Ruefli-Brasse et al. (see the Perspective by Yu and Lenardo) show that the caspase-like protein, paracaspase, is essential for lymphocyte function and acts downstream of CARMA1 and Bcl10. Impaired paracaspase-dependent activation of the kinase complex that normally facilitates NF-B activation caused T and B cells from paracaspase-deficient mice to respond poorly to receptor signals.
Citation: Controlling Immunological Signaling. Sci. STKE 2003, tw468 (2003).
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