Sci. STKE, 2 December 2003
PHYSIOLOGY Genetics of a Coronary Vascular Disorder
The genetic factors influencing coronary artery disease (CAD) remain poorly defined. Wang et al. studied a large family with high incidence of a vascular condition resembling CAD, which in most of the cases led to myocardial infarction. A genome-wide linkage analysis identified an autosomal dominant locus that included MEF2A, an endothelial transcription factor that is thought to participate in vascular development. A deletion-mutation within MEF2A that conferred altered cellular distribution of the protein specifically segregated with genes of family members having the CAD-like vascular condition. It remains to be seen whether the MEF2A pathway plays a role in the common form of CAD resulting from atherosclerosis.
Citation: Genetics of a Coronary Vascular Disorder. Sci. STKE 2003, tw469 (2003).
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