Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 9 December 2003
Vol. 2003, Issue 212, p. tw480
[DOI: 10.1126/stke.2122003TW480]


CELL BIOLOGY Smurfing Cell Polarity

The Rho family of small guanosine triphosphatases (GTPases) is critical for controlling cell shape, motility, polarity, and behavior in development and tumor progression. However, little is known about how the activity of different Rho GTPases is spatially coordinated to control these processes. Wang et al. (see the Perspective by Jaffe and Hall) examined the role of Smurf1, a HECT domain E3 ubiquitin ligase that modulates Smad signaling. The localization of Smurf1 to lamellipodia and filopodia required the activity of atypical protein kinase zeta, an effector involved in establishing cell polarity. Smurf1 controls the local level of RhoA whose accumulation in cellular protrusions is linked to the suppression of the transformed phenotype induced by knocking down Smurf1 expression.

H.-R. Wang, Y. Zhang, B. Ozdamar, A. A. Ogunjimi, E. Alexandrova, G. H. Thomsen, J. L. Wrana, Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science 302, 1775-1779 (2003). [Abstract] [Full Text]

A. B. Jaffe, A. Hall, Smurfing at the leading edge. Science 302, 1690-1691 (2003). [SUmmary] [Full Text]

Citation: Smurfing Cell Polarity. Sci. STKE 2003, tw480 (2003).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882