Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 6 January 2004
Vol. 2004, Issue 214, p. tw10
[DOI: 10.1126/stke.2142004tw10]


CHANNELS Generating Tubes During Development

In the animal world, the development of several organs involves tube formation, for example, the development of kidney, lung, and blood vessels. Berry et al. (see the Perspective by Paul and Beitel) examined genes required for proper tube formation and/or maintenance in the excretory system of the nematode, Caenorhabditis elegans. They identified and characterized a putative intracellular chloride channel that functions early in tube morphogenesis, at about the time the lumen begins to form. Mutations in this gene lead to the formation of cysts rather than a continuous luminal channel in the developing excretory system.

K. L. Berry, H. E. Bülow, D. H. Hall, O. Hobert, A C. elegans CLIC-like protein required for intracellular tube formation and maintenance. Science 302, 2134-2137 (2003). [Abstract] [Full Text]

S. M. Paul, G. J. Beitel, Tubulogenesis CLICs into place. Science 302, 2077-2078 (2003). [Abstract] [Full Text]

Citation: Generating Tubes During Development. Sci. STKE 2004, tw10 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882