Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 20 January 2004
Vol. 2004, Issue 216, p. pe2
[DOI: 10.1126/stke.2162004pe2]

PERSPECTIVES

Epithelial Barriers, Compartmentation, and Cancer

J. M. Mullin*

Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA.

Abstract: Epithelial cells, and the tight junctions between them, form a polarized barrier between luminal and serosal fluid compartments and segregate luminal growth factors from their basal-lateral receptors. Breakdown of this barrier should allow access of growth factors in the luminal fluid to their receptors on the basal-lateral cell membranes, as recently demonstrated for heregulin and erbB receptors in airway epithelia. It should also allow luminal growth factors to access the stroma. This property may have adaptive value for epithelial tissues in general, as an elegant response to injury, but may also promote cancer formation in premalignant epithelial tissues in which the tight junctions have become chronically leaky to growth factors.

*Corresponding author. E-mail: mullinj{at}mlhs.org

Citation: J. M. Mullin, Epithelial Barriers, Compartmentation, and Cancer. Sci. STKE 2004, pe2 (2004).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Claudin-3 and Claudin-4 Regulate Sensitivity to Cisplatin by Controlling Expression of the Copper and Cisplatin Influx Transporter CTR1.
X. Shang, X. Lin, G. Manorek, and S. B. Howell (2013)
Mol. Pharmacol. 83, 85-94
   Abstract »    Full Text »    PDF »
Decreased Expression of Claudin-1 in Rectal Cancer: A Factor for Recurrence and Poor Prognosis.
T. YOSHIDA, T. KINUGASA, Y. AKAGI, A. KAWAHARA, K. ROMEO, I. SHIRATSUCHI, Y. RYU, Y. GOTANDA, and K. SHIROUZU (2011)
Anticancer Res 31, 2517-2525
   Abstract »    Full Text »    PDF »
Dietary methionine restriction improves colon tight junction barrier function and alters claudin expression pattern.
A. Ramalingam, X. Wang, M. Gabello, M. C. Valenzano, A. P. Soler, A. Ko, P. J. Morin, and J. M. Mullin (2010)
Am J Physiol Cell Physiol 299, C1028-C1035
   Abstract »    Full Text »    PDF »
Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin.
S. K. Harten, D. Shukla, R. Barod, A. Hergovich, M. S. Balda, K. Matter, M. A. Esteban, and P. H. Maxwell (2009)
Mol. Biol. Cell 20, 1089-1101
   Abstract »    Full Text »    PDF »
Helicobacter pylori and Gastric Cancer: What can be Learned by Studying the Response of Gastric Epithelial Cells to the Infection?.
A. Mueller, S. Falkow, and M. R. Amieva (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1859-1864
   Abstract »    Full Text »    PDF »
Signaling the Junctions in Gut Epithelium.
F. Hollande, A. Shulkes, and G. S. Baldwin (2005)
Sci. STKE 2005, pe13
   Abstract »    Full Text »    PDF »
Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia.
F. C. Morales, Y. Takahashi, E. L. Kreimann, and M.-M. Georgescu (2004)
PNAS 101, 17705-17710
   Abstract »    Full Text »    PDF »
Barriers built on claudins.
K. Turksen and T.-C. Troy (2004)
J. Cell Sci. 117, 2435-2447
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882