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Sci. STKE, 20 January 2004
Vol. 2004, Issue 216, p. pe3
[DOI: 10.1126/stke.2162004pe3]


A New Look at an Old Problem: The Survival and Organ-Specific Growth of Metastases

Donald J. Vander Griend and Carrie W. Rinker-Schaeffer*

Section of Urology MC6038, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.

Abstract: Despite improvements in cancer detection and therapy, metastatic disease is largely incurable. Recent research indicates that tumor cells disseminate widely early in the process of pathogenesis, and that the survival and proliferation of these cells--and thus the development of metastases--depend on interactions between the disseminated cells and their particular microenvironment. Proliferative signals and the inhibition of proapoptotic responses are both critically involved in the development of clinically significant metastases. Identification of the underlying signaling cascades may provide additional targets for antimetastatic therapy.

*Corresponding author. Telephone, 773-702-5882; fax, 773-702-1001; e-mail, crinkers{at}

Citation: D. J. Vander Griend, C. W. Rinker-Schaeffer, A New Look at an Old Problem: The Survival and Organ-Specific Growth of Metastases. Sci. STKE 2004, pe3 (2004).

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Suppression of Metastatic Colonization by the Context-Dependent Activation of the c-Jun NH2-Terminal Kinase Kinases JNKK1/MKK4 and MKK7.
D. J. Vander Griend, M. Kocherginsky, J. A. Hickson, W. M. Stadler, A. Lin, and C. W. Rinker-Schaeffer (2005)
Cancer Res. 65, 10984-10991
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