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Sci. STKE, 3 February 2004
Vol. 2004, Issue 218, p. tw41
[DOI: 10.1126/stke.2182004TW41]

EDITORS' CHOICE

DEVELOPMENTAL BIOLOGY Blocking Low-Level Signals

Development of the vulva in the nematode Caenorhabditis elegans has been used as a model system for examining the patterning of cell fate in an animal. Two different intercellular signals contribute to distinguish cell fate among vulval precursor cells (VPCs): a long-range spatial gradient of epidermal growth factor (EGF) mediated by the EGF receptor and a cell-to-cell lateral signal mediated by the Notch-like receptor LIN-12. Yoo et al. (see the Perspective by Sternberg) now find that VPCs activated by a low level of EGF are blocked from adopting a particular cell fate by a LIN-12 lateral signal from a neighboring cell.

A. S. Yoo, C. Bais, I. Greenwald, Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science 303, 663-666 (2004). [Abstract] [Full Text]

P. W. Sternberg, A pattern of precision. Science 303, 637-638 (2004). [Summary] [Full Text]

Citation: Blocking Low-Level Signals. Sci. STKE 2004, tw41 (2004).

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