Sci. STKE, 3 February 2004
DEVELOPMENTAL BIOLOGY Blocking Low-Level Signals
Development of the vulva in the nematode Caenorhabditis elegans has been used as a model system for examining the patterning of cell fate in an animal. Two different intercellular signals contribute to distinguish cell fate among vulval precursor cells (VPCs): a long-range spatial gradient of epidermal growth factor (EGF) mediated by the EGF receptor and a cell-to-cell lateral signal mediated by the Notch-like receptor LIN-12. Yoo et al. (see the Perspective by Sternberg) now find that VPCs activated by a low level of EGF are blocked from adopting a particular cell fate by a LIN-12 lateral signal from a neighboring cell.
Citation: Blocking Low-Level Signals. Sci. STKE 2004, tw41 (2004).
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