Sci. STKE, 3 February 2004
REPRODUCTIVE BIOLOGY Factor Cascade
During the middle part of the mammalian reproductive cycle, a surge of luteinizing hormone (LH) is followed by a series of changes in the ovarian follicle, including resumption of oocyte meiosis and increased gene expression in cells surrounding the oocyte. The end point of these changes is follicle rupture and ovulation of a fertilizable egg. It has been unclear how LH participates in this series of events, because the oocyte and surrounding cumulus cells do not respond directly to LH and do not express LH receptors. Park et al. show that LH operates via intermediary factors of the epidermal growth factor family to trigger cumulus expansion and oocyte meiotic maturation. Elucidation of LH action on the ovary may be useful in manipulating follicular function in the treatment of infertility.
Citation: Factor Cascade. Sci. STKE 2004, tw42 (2004).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882