Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 3 February 2004
Vol. 2004, Issue 218, p. tw42
[DOI: 10.1126/stke.2182004TW42]

EDITORS' CHOICE

REPRODUCTIVE BIOLOGY Factor Cascade

During the middle part of the mammalian reproductive cycle, a surge of luteinizing hormone (LH) is followed by a series of changes in the ovarian follicle, including resumption of oocyte meiosis and increased gene expression in cells surrounding the oocyte. The end point of these changes is follicle rupture and ovulation of a fertilizable egg. It has been unclear how LH participates in this series of events, because the oocyte and surrounding cumulus cells do not respond directly to LH and do not express LH receptors. Park et al. show that LH operates via intermediary factors of the epidermal growth factor family to trigger cumulus expansion and oocyte meiotic maturation. Elucidation of LH action on the ovary may be useful in manipulating follicular function in the treatment of infertility.

J.-Y. Park, Y.-Q. Su, M. Ariga, E. Law, S.-L. C. Jin, M. Conti, EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science 303, 682-684 (2004). [Abstract] [Full Text]

Citation: Factor Cascade. Sci. STKE 2004, tw42 (2004).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882