Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 3 February 2004
Vol. 2004, Issue 218, p. tw45
[DOI: 10.1126/stke.2182004TW45]


IMMUNOLOGY Tipping the Scales

Effective immune responses depend on the precise activation and deactivation of signaling cascades by protein tyrosine kinases (PTKs) and phosphatases (PTPases). The PEST domain-enriched tyrosine phosphatase (PEP) is one such PTPase, which opposes T cell receptor signaling. Hasegawa et al. report that the loss of PEP activity in mice produced unchecked effector and memory T cell responses. Although this stopped short of causing overt autoimmunity in PEP-deficient mice, excessive B cell responses were evident, which suggests a role for the phosphatase in regulating diverse aspects of T cell-coordinated immunity.

K. Hasegawa, F. Martin, G. Huang, D. Tumas, L. Diehl, A. C. Chan, PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 303, 685-689 (2004). [Abstract] [Full Text]

Citation: Tipping the Scales. Sci. STKE 2004, tw45 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882