Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 10 February 2004
Vol. 2004, Issue 219, p. tw55
[DOI: 10.1126/stke.2192004TW55]


NETWORKS Genetic Interaction Network

Understanding the topology of genetic networks and their functional order may enable human geneticists to develop new approaches for identifying disease genes associated with complex traits. Tong et al. (see the Perspective by Hartwell) have used double mutants to examine the network of genetic interactions in yeast. The yeast genetic network appeared to have 5 to 10 times the complexity of the protein interaction network, although it also followed a power law distribution and exhibited small-world properties. The position and connectivity of a gene within the network made it possible to predict molecular roles for previously uncharacterized genes that were supported by experimental data.

A. H. Y. Tong, G. Lesage, G. D. Bader, H. Ding, H. Xu, X. Xin, J. Young, G. F. Berriz, R. L. Brost, M. Chang, Y. Chen, X. Cheng, G. Chua, H. Friesen, D. S. Goldberg, J. Haynes, C. Humphries, G. He, S. Hussein, L. Ke, N. Krogan, Z. Li, J. N. Levinson, H. Lu, P. Ménard, C. Munyana, A. B. Parsons, O. Ryan, R. Tonikian, T. Roberts, A.-M. Sdicu, J. Shapiro, B. Sheikh, B. Suter, S. L. Wong, L. V. Zhang, H. Zhu, C. G. Burd, S. Munro, C. Sander, J. Rine, J. Greenblatt, M. Peter, A. Bretscher, G. Bell, F. P. Roth, G. W. Brown, B. Andrews, H. Bussey, C. Boone, Global mapping of the yeast genetic interaction network. Science 303, 808-813 (2004). [Abstract] [Full Text]

L. Hartwell, Robust interactions. Science 303, 774-775 (2004). [Summary] [Full Text]

Citation: Genetic Interaction Network. Sci. STKE 2004, tw55 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882