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Sci. STKE, 17 February 2004
Vol. 2004, Issue 220, p. tw65
[DOI: 10.1126/stke.2202004TW65]

EDITORS' CHOICE

IMMUNOLOGY Forkhead and Autoimmunity

The forkhead family of transcription factors are involved in a variety of systems. The forkhead family member Foxj1 is thought to play a role in the immune system, but genetic deficiency of this factor proves lethal, making direct in vivo analysis difficult. To overcome this, Lin et al. devised a chimeric system in mice, in which effects of Foxj1 deficiency could be explored. In these chimeras, foxj1–/– T cells displayed an exaggerated inflammatory cytokine expression, which eventually generated systemic autoimmunity. Normal repression of cytokine production by Foxj1 resulted from inhibition of the transcriptional activator nuclear factor NF-{kappa}B, possibly via the up-regulation of the inhibitory NF-{kappa}B cofactor, I{kappa}B.

L. Lin, M. S. Spoor, A. J. Gerth, S. L. Brody, S. L. Peng, Modulation of TH1 activation and inflammation by the NF-{kappa}B repressor Foxj1. Science 303, 1017-1020 (2004). [Abstract] [Full Text]

Citation: Forkhead and Autoimmunity. Sci. STKE 2004, tw65 (2004).

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