Sci. STKE, 17 February 2004
IMMUNOLOGY Forkhead and Autoimmunity
The forkhead family of transcription factors are involved in a variety of systems. The forkhead family member Foxj1 is thought to play a role in the immune system, but genetic deficiency of this factor proves lethal, making direct in vivo analysis difficult. To overcome this, Lin et al. devised a chimeric system in mice, in which effects of Foxj1 deficiency could be explored. In these chimeras, foxj1–/– T cells displayed an exaggerated inflammatory cytokine expression, which eventually generated systemic autoimmunity. Normal repression of cytokine production by Foxj1 resulted from inhibition of the transcriptional activator nuclear factor NF-B, possibly via the up-regulation of the inhibitory NF-B cofactor, IB.
Citation: Forkhead and Autoimmunity. Sci. STKE 2004, tw65 (2004).
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