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Sci. STKE, 24 February 2004
Vol. 2004, Issue 221, p. pe6
[DOI: 10.1126/stke.2212004pe6]


The Role of Membrane-Bound Ankyrin-Repeat Protein ACD6 in Programmed Cell Death and Plant Defense

Xinnian Dong*

Developmental, Cell and Molecular Biology Group, LSRC Building, Duke University, Durham, NC 27708, USA.

Abstract: Programmed cell death (PCD) is a common defense response in plants against pathogen infection. The recently cloned ACD6 gene was identified in an Arabidopsis mutant, accelerated cell death 6 (acd6), that undergoes PCD in the absence of a pathogen challenge. ACD6 is a founding member of a large family of genes that encode proteins with a short amino-terminal region, nine ankyrin repeats in the middle, and five putative transmembrane domains in the carboxyl-terminal region. Characterization of the original gain-of-function acd6 mutant and a transferred-DNA knockout mutant acd6-T showed that ACD6 is an activator of the defense pathway against bacterial pathogens and plays a role in PCD through regulation of the defense signal salicylic acid (SA). SA mediates not only downstream pathogenesis-related (PR) genes, which encode proteins with antimicrobial activities, but also ACD6, forming a feedback signal amplification loop.

*Contact information. Telephone, 919-613-8176; fax, 919-613-8177; e-mail,

Citation: X. Dong, The Role of Membrane-Bound Ankyrin-Repeat Protein ACD6 in Programmed Cell Death and Plant Defense. Sci. STKE 2004, pe6 (2004).

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