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Sci. STKE, 24 February 2004 PERSPECTIVESThe Role of Membrane-Bound Ankyrin-Repeat Protein ACD6 in Programmed Cell Death and Plant DefenseDevelopmental, Cell and Molecular Biology Group, LSRC Building, Duke University, Durham, NC 27708, USA. Summary: Programmed cell death (PCD) is a common defense response in plants against pathogen infection. The recently cloned ACD6 gene was identified in an Arabidopsis mutant, accelerated cell death 6 (acd6), that undergoes PCD in the absence of a pathogen challenge. ACD6 is a founding member of a large family of genes that encode proteins with a short amino-terminal region, nine ankyrin repeats in the middle, and five putative transmembrane domains in the carboxyl-terminal region. Characterization of the original gain-of-function acd6 mutant and a transferred-DNA knockout mutant acd6-T showed that ACD6 is an activator of the defense pathway against bacterial pathogens and plays a role in PCD through regulation of the defense signal salicylic acid (SA). SA mediates not only downstream pathogenesis-related (PR) genes, which encode proteins with antimicrobial activities, but also ACD6, forming a feedback signal amplification loop. *Contact information. Telephone, 919-613-8176; fax, 919-613-8177; e-mail, xdong@duke.edu
Citation: X. Dong, The Role of Membrane-Bound Ankyrin-Repeat Protein ACD6 in Programmed Cell Death and Plant Defense. Sci. STKE 2004, pe6 (2004). |
Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
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