Sci. STKE, 24 February 2004
CANCER BIOLOGY Tumor Suppressor Doing Double Duty
The tumor suppressor protein PTEN is a dual-specificity phosphatase whose catalytic domain acts primarily on lipids but can also target proteins. Raftopoulou et al. report that PTEN lipid phosphatase activity is not required for PTEN to inhibit cell migration. Instead, its protein phosphatase activity is required to dephosphorylate a single residue in its C-terminal tail, which in turn regulates migration. This mechanism may contribute to the progression of tumors that harbor catalytically inactive forms of PTEN.
Citation: Tumor Suppressor Doing Double Duty. Sci. STKE 2004, tw74 (2004).
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