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Sci. STKE, 2 March 2004
Vol. 2004, Issue 222, p. pe8
[DOI: 10.1126/stke.2222004pe8]

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Molecular Interaction Maps--A Diagrammatic Graphical Language for Bioregulatory Networks

Mirit I. Aladjem1*, Stefania Pasa2, Silvio Parodi2, John N. Weinstein1, Yves Pommier1, and Kurt W. Kohn1*

1Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
2Laboratory of Experimental Oncology, National Institute of Cancer Research and University of Genoa, Genoa, Italy.

Abstract: Molecular interaction maps (MIMs) use a clear, accurate, and versatile graphical language to depict complex biological processes. Here, we discuss the main features of the MIM language and its potential uses. MIMs can be used as database resources and simulation guides, and can serve to generate new hypotheses regarding the roles of specific molecules in the bioregulatory networks that control progression through the cell cycle, differentiation, and cell death.

*Corresponding authors. E-mail: aladjemm{at}mail.nih.gov (M.I.A.); kohnk{at}dc37a.nci.nih.gov (K.W.K).

Citation: M. I. Aladjem, S. Pasa, S. Parodi, J. N. Weinstein, Y. Pommier, K. W. Kohn, Molecular Interaction Maps--A Diagrammatic Graphical Language for Bioregulatory Networks. Sci. STKE 2004, pe8 (2004).

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