|
Sci. STKE, 2 March 2004 EDITORS' CHOICEUBIQUITINATION Life or Death Transcription FactorsTight control of the levels of the transcription factor and proto-oncogene c-Jun determines in part whether the outcome for the cells is survival or programmed cell death (apoptosis). Two independent groups have identified c-Jun-specific ubiquitin ligases that control the turnover of c-Jun in mammalian cells. Nateri et al. characterized c-Jun degradation stimulated by the ubiquitin ligase complex SCFFbw7. The activity of the SCFFbw7 pathway in promoting the degradation of c-Jun allows neurons to survive conditions that would otherwise lead to cell death. Wertz et al. report that the DCXhDET1-hCOP1 ubiquitin ligase complex can also promote c-Jun degradation and thereby protect mammalian cells from apoptosis. Because c-Jun controls a large number of cellular processes, it is not surprising that more than one ubiquitin ligase controls c-Jun levels. A. S. Nateri, L. Riera-Sans, C. Da Costa, A. Behrens, The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 303, 1374-1378 (2004). [Abstract] [Full Text] I. E. Wertz, K. M. O'Rourke, Z. Zhang, D. Dornan, D. Arnott, R. J. Deshaies, V. M. Dixit, Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303, 1371-1374 (2004). [Abstract] [Full Text]
Citation: Life or Death Transcription Factors. Sci. STKE 2004, tw80 (2004). |
Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
Magazine | News | Signaling | Careers | Multimedia | Collections | Help | Site Map | RSS
Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us
© 2004 American Association for the Advancement of Science. All Rights Reserved.
AAAS is a partner of HINARI, AGORA, PatientInform, CrossRef, and COUNTER.
You have reached the bottom of the page. Back to top