Sci. STKE, 2 March 2004
UBIQUITINATION Life or Death Transcription Factors
Tight control of the levels of the transcription factor and proto-oncogene c-Jun determines in part whether the outcome for the cells is survival or programmed cell death (apoptosis). Two independent groups have identified c-Jun-specific ubiquitin ligases that control the turnover of c-Jun in mammalian cells. Nateri et al. characterized c-Jun degradation stimulated by the ubiquitin ligase complex SCFFbw7. The activity of the SCFFbw7 pathway in promoting the degradation of c-Jun allows neurons to survive conditions that would otherwise lead to cell death. Wertz et al. report that the DCXhDET1-hCOP1 ubiquitin ligase complex can also promote c-Jun degradation and thereby protect mammalian cells from apoptosis. Because c-Jun controls a large number of cellular processes, it is not surprising that more than one ubiquitin ligase controls c-Jun levels.
I. E. Wertz, K. M. O'Rourke, Z. Zhang, D. Dornan, D. Arnott, R. J. Deshaies, V. M. Dixit, Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303, 1371-1374 (2004). [Abstract] [Full Text]
Citation: Life or Death Transcription Factors. Sci. STKE 2004, tw80 (2004).
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