Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Signal Transduction Society

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 16 March 2004
Vol. 2004, Issue 224, p. pe10
[DOI: 10.1126/stke.2242004pe10]

PERSPECTIVES

Sensing Cellular Stress: Another New Function for the Nucleolus?

Mark O. J. Olson*

Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Summary: Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.

*Contact information. Telephone, 601-984-1500; fax, 601-984-1501; e-mail, molson{at}biochem.umsmed.edu

Citation: M. O. J. Olson, Sensing Cellular Stress: Another New Function for the Nucleolus? Sci. STKE 2004, pe10 (2004).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells.
J.-L. Prieto and B. McStay (2007)
Genes & Dev. 21, 2041-2054
   Abstract »    Full Text »    PDF »
Nuclear and Nucleolar Targeting of Influenza A Virus NS1 Protein: Striking Differences between Different Virus Subtypes.
K. Melen, L. Kinnunen, R. Fagerlund, N. Ikonen, K. Y. Twu, R. M. Krug, and I. Julkunen (2007)
J. Virol. 81, 5995-6006
   Abstract »    Full Text »    PDF »
NOPdb: Nucleolar Proteome Database.
A. K. L. Leung, L. Trinkle-Mulcahy, Y. W. Lam, J. S. Andersen, M. Mann, and A. I. Lamond (2006)
Nucleic Acids Res. 34, D218-D220
   Abstract »    Full Text »    PDF »
The Homologous Putative GTPases Grn1p from Fission Yeast and the Human GNL3L Are Required for Growth and Play a Role in Processing of Nucleolar Pre-rRNA.
X. Du, M. R.K. S. Rao, X. Q. Chen, W. Wu, S. Mahalingam, and D. Balasundaram (2006)
Mol. Biol. Cell 17, 460-474
   Abstract »    Full Text »    PDF »
DNA Damage Disrupts the p14ARF-B23(Nucleophosmin) Interaction and Triggers a Transient Subnuclear Redistribution of p14ARF.
C. Lee, B. A. Smith, K. Bandyopadhyay, and R. A. Gjerset (2005)
Cancer Res. 65, 9834-9842
   Abstract »    Full Text »    PDF »
The Shwachman-Diamond SBDS protein localizes to the nucleolus.
K. M. Austin, R. J. Leary, and A. Shimamura (2005)
Blood 106, 1253-1258
   Abstract »    Full Text »    PDF »
Dynamic Sorting of Nuclear Components into Distinct Nucleolar Caps during Transcriptional Inhibition.
Y. Shav-Tal, J. Blechman, X. Darzacq, C. Montagna, B. T. Dye, J. G. Patton, R. H. Singer, and D. Zipori (2005)
Mol. Biol. Cell 16, 2395-2413
   Abstract »    Full Text »    PDF »

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)