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Sci. STKE, 16 March 2004
Vol. 2004, Issue 224, p. pe10
[DOI: 10.1126/stke.2242004pe10]

PERSPECTIVES

Sensing Cellular Stress: Another New Function for the Nucleolus?

Mark O. J. Olson*

Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Abstract: Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.

*Contact information. Telephone, 601-984-1500; fax, 601-984-1501; e-mail, molson{at}biochem.umsmed.edu

Citation: M. O. J. Olson, Sensing Cellular Stress: Another New Function for the Nucleolus? Sci. STKE 2004, pe10 (2004).

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