Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 16 March 2004
Vol. 2004, Issue 224, p. pe11
[DOI: 10.1126/stke.2242004pe11]


Promiscuity Rules? The Dispensability of Cyclin E and Cdk2

Tin Tin Su* and Jason Stumpff

MCD Biology, University of Colorado, Boulder, CO 80309-0347, USA.

Abstract: The canonical view of the mammalian cell cycle arose from studies of cultured cells rather than mutant organisms. It depicts the many complexes of cyclin and Cdk (cyclin/Cdk) as fulfilling unique and essential steps that dictate the sequential order of cell cycle events. Recent analyses of knockout mice challenge this view. Cdk2 and cyclin E, long thought to be essential, are largely dispensable. Here, we discuss the phenotypes of these and other cyclin/Cdk mutants in genetically tractable metazoa (mouse, fly, and nematode) and explore possible reasons behind similarities and differences among experimental systems and cell types.

*Corresponding author. E-mail:{at}

Citation: T. T. Su, J. Stumpff, Promiscuity Rules? The Dispensability of Cyclin E and Cdk2. Sci. STKE 2004, pe11 (2004).

Read the Full Text

UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.
J. Chu, E. A. Loughlin, N. A. Gaur, S. SenBanerjee, V. Jacob, C. Monson, B. Kent, A. Oranu, Y. Ding, C. Ukomadu, et al. (2012)
Mol. Biol. Cell 23, 59-70
   Abstract »    Full Text »    PDF »
Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding.
G. Pascreau, F. Eckerdt, M. E. A. Churchill, and J. L. Maller (2010)
PNAS 107, 2932-2937
   Abstract »    Full Text »    PDF »
Indole-3-Carbinol (I3C) Inhibits Cyclin-dependent Kinase-2 Function in Human Breast Cancer Cells by Regulating the Size Distribution, Associated Cyclin E Forms, and Subcellular Localization of the CDK2 Protein Complex.
H. H. Garcia, G. A. Brar, D. H. H. Nguyen, L. F. Bjeldanes, and G. L. Firestone (2005)
J. Biol. Chem. 280, 8756-8764
   Abstract »    Full Text »    PDF »
CDK4 regulation by TNFR1 and JNK is required for NF-{kappa}B-mediated epidermal growth control.
J. Y. Zhang, S. Tao, R. Kimmel, and P. A. Khavari (2005)
J. Cell Biol. 168, 561-566
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882