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Sci. STKE, 23 March 2004
Vol. 2004, Issue 225, p. pe14
[DOI: 10.1126/stke.2252004pe14]


Accessing Natural Products by Combinatorial Biosynthesis

Ben Shen*

Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin–Madison, 777 Highland Avenue, Madison, WI 53705, USA.

Abstract: Enhancement and selective production of the protein phosphatase IIa inhibitor phoslactomycin (PLM) B by rational engineering of the PLM biosynthetic pathway highlights the effectiveness of combinatorial biosynthesis as a promising way to prepare complex natural products and their analogs.

*Contact information. Telephone, 608-263-2673; fax, 608-262-5345; e-mail, bshen{at}

Citation: B. Shen, Accessing Natural Products by Combinatorial Biosynthesis. Sci. STKE 2004, pe14 (2004).

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From The Cover: Combinatorial biosynthesis of antitumor indolocarbazole compounds.
C. Sanchez, L. Zhu, A. F. Brana, A. P. Salas, J. Rohr, C. Mendez, and J. A. Salas (2005)
PNAS 102, 461-466
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