Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 23 March 2004
Vol. 2004, Issue 225, p. pe14
[DOI: 10.1126/stke.2252004pe14]

PERSPECTIVES

Accessing Natural Products by Combinatorial Biosynthesis

Ben Shen*

Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin–Madison, 777 Highland Avenue, Madison, WI 53705, USA.

Abstract: Enhancement and selective production of the protein phosphatase IIa inhibitor phoslactomycin (PLM) B by rational engineering of the PLM biosynthetic pathway highlights the effectiveness of combinatorial biosynthesis as a promising way to prepare complex natural products and their analogs.

*Contact information. Telephone, 608-263-2673; fax, 608-262-5345; e-mail, bshen{at}pharmacy.wisc.edu

Citation: B. Shen, Accessing Natural Products by Combinatorial Biosynthesis. Sci. STKE 2004, pe14 (2004).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
From The Cover: Combinatorial biosynthesis of antitumor indolocarbazole compounds.
C. Sanchez, L. Zhu, A. F. Brana, A. P. Salas, J. Rohr, C. Mendez, and J. A. Salas (2005)
PNAS 102, 461-466
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882