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Sci. STKE, 30 March 2004
Vol. 2004, Issue 226, p. tw119
[DOI: 10.1126/stke.2262004TW119]


PLANT BIOLOGY Plant MicroRNAs Fail to Make the Cut

The functions of the multitudinous microRNAs found in most eukaryotic organisms are slowly beginning to emerge, with recent research in human tissue-culture cells and Drosophila adding to our knowledge of the roles of the founder members of the group, let7 and lin4, in the nematode worm Caenorhabditis elegans. Chen now shows that the miRNA172 family of microRNAs regulates flower development in Arabidopsis through the floral homeotic gene APETALA2. Furthermore, miRNA172 works by repressing the translation of the APETALA2 messenger RNA, contrary to recent expectations that plant miRNAs function by cleaving their target RNAs. Thus, this plant miRNA works like a typical animal miRNA.

X. Chen, A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Science 303, 2022-2025 (2004). [Abstract] [Full Text]

Citation: Plant MicroRNAs Fail to Make the Cut. Sci. STKE 2004, tw119 (2004).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882