Sci. STKE, 13 April 2004
CHANNELS Membrane Effects on Ion Channel Function
What is the effect of the membrane environment on ion channel function? Are ion channel subunits solely responsible for channel properties, or can lipids alter the gating of potassium channels? Oliver et al. (see the Perspective by Hilgemann) demonstrate that membrane lipids can convert A-type potassium channels into delayed rectifiers, and vice versa. Phosphoinositides such as PIP2 immobilize the inactivation domain and thus remove N-type inactivation from A-type potassium channels. Conversely, the fatty acids arachidonic acid and anandamide equip delayed-rectifier channels with rapid voltage-dependent inactivation.
D. Oliver, C.-C. Lien, M. Soom, T. Baukrowitz, P. Jonas, B. Fakler, Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science 304, 265-270 (2004). [Abstract] [Full Text]
Citation: Membrane Effects on Ion Channel Function. Sci. STKE 2004, tw136 (2004).
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