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Sci. STKE, 20 April 2004
Vol. 2004, Issue 229, p. pe18
[DOI: 10.1126/stke.2292004pe18]


Glioblastomas on the Move

Adrian Merlo1* and Bernhard Bettler2

1Department of Clinical-Biological Sciences, University Hospitals, University of Basel, Switzerland.
2Institute of Physiology, University of Basel, Switzerland.

Abstract: The mechanism by which the tumor suppressor PTEN slows tumor cell migration is not well characterized. A recent study by Raftopoulou et al. shows that a lack of PTEN protein phosphatase activity accelerates the migration of glioblastoma cells. The protein phosphatase activity of PTEN is directly or indirectly responsible for dephosphorylating a PTEN residue, threonine-383, which is necessary for slowing cell migration. These findings have implications for the design of new therapies against glioblastomas and other highly invasive cancers.

*Corresponding author. Neurosurgery and Department of Research, University Hospitals, Spitalstrasse 21, CH-4031 Basel, Switzerland. E-mail: amerlo{at}

Citation: A. Merlo, B. Bettler, Glioblastomas on the Move. Sci. STKE 2004, pe18 (2004).

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