Sci. STKE, 20 April 2004
VESICLE FUSION Sensing Calcium During Membrane Fusion
The minimal machinery required for calcium-stimulated fusion, such as occurs during regulated secretion or neurotransmitter release, has been the subject of much controversy. Using a reconstituted system, Tucker et al. now show a robust requirement for the cytoplasmic tail of the synaptic vesicle protein synaptotagmin to act as a calcium sensor during SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor)-mediated fusion in reconstituted liposomes.
Citation: Sensing Calcium During Membrane Fusion. Sci. STKE 2004, tw147 (2004).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882