Sci. STKE, 27 April 2004
Gene Expression MicroRNA in HOX
Homeobox (HOX) genes are highly conserved transcriptional regulators that play a central role in development and pattern formation of higher eukaryotes. Genes encoding microRNAs, tiny 22-nucleotide RNAs involved in gene silencing, are found in almost all eukaryotes and have been implicated in a number of important cell and developmental pathways. Yekta et al. now show that an evolutionarily conserved and essentially complementary binding site for the miRNA miR-196 is found in the HOX gene HOX8B. miR-196 directs the cleavage of HOX8B messenger RNA during mouse development, and other evidence suggests that miR-196 can regulate the translation of other HOX genes in the mouse HOX cluster.
Citation: MicroRNA in HOX. Sci. STKE 2004, tw152 (2004).
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