Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 27 April 2004
Vol. 2004, Issue 230, p. tw155
[DOI: 10.1126/stke.2302004TW155]

EDITORS' CHOICE

Neurobiology Recordings from Synfire Chains

The idea that the nervous system plays out highly specific patterns of network activity may be a key step in closing the gap between neural network models and experimental neurophysiology. Theoreticians have long proposed that cortical activity takes the form of sequences of synchronous activity, the so-called synfire chains. Ikegaya et al. (see the Perspective by Abeles) used brain slice intracellular recordings to show patterns of postsynaptic currents, optical recordings of slice, and in vivo multicellular recordings to demonstrate the existence of these chains. Blocking NMDA or dopamine D1 receptors also reduced the chains.

Y. Ikegaya, G. Aaron, R. Cossart, D. Aronov, I. Lampl, D. Ferster, R. Yuste, Synfire chains and cortical songs: Temporal modules of cortical activity. Science 304, 559-564 (2004). [Abstract] [Full Text]

M. Abeles, Time is precious. Science 304, 523-524 (2004). [Summary] [Full Text]

Citation: Recordings from Synfire Chains. Sci. STKE 2004, tw155 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882