Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 18 May 2004
Vol. 2004, Issue 233, p. pe22
[DOI: 10.1126/stke.2332004pe22]


Metabolic Modulation of Potassium Channels

Dirk Trauner1* and Richard H. Kramer2

1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Abstract: Recent investigations have shown that a range of small molecules that reflect the metabolic state of a cell regulate the activity of potassium channels. For instance, hydrogen peroxide has been shown to activate adenosine 5'-triphosphate–sensitive potassium channels (KATP channels), whereas heme closes certain calcium-activated potassium channels. Although the exact function of the β subunit associated with voltage-gated potassium channels is still unclear, its crystal structure suggests that membrane excitability is directly coupled to metabolism.

*Corresponding author. E-mail: trauner{at}

Citation: D. Trauner, R. H. Kramer, Metabolic Modulation of Potassium Channels. Sci. STKE 2004, pe22 (2004).

Read the Full Text

Oxidative modification of M-type K+ channels as a mechanism of cytoprotective neuronal silencing.
N. Gamper, O. Zaika, Y. Li, P. Martin, C. C. Hernandez, M. R. Perez, A. Y. Wang, D. B. Jaffe, and M. S. Shapiro (2006)
EMBO J. 25, 4996-5004
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882