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Sci. STKE, 18 May 2004
Vol. 2004, Issue 233, p. pe22
[DOI: 10.1126/stke.2332004pe22]

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Metabolic Modulation of Potassium Channels

Dirk Trauner1* and Richard H. Kramer2

1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Abstract: Recent investigations have shown that a range of small molecules that reflect the metabolic state of a cell regulate the activity of potassium channels. For instance, hydrogen peroxide has been shown to activate adenosine 5'-triphosphate–sensitive potassium channels (KATP channels), whereas heme closes certain calcium-activated potassium channels. Although the exact function of the β subunit associated with voltage-gated potassium channels is still unclear, its crystal structure suggests that membrane excitability is directly coupled to metabolism.

*Corresponding author. E-mail: trauner{at}cchem.berkeley.edu

Citation: D. Trauner, R. H. Kramer, Metabolic Modulation of Potassium Channels. Sci. STKE 2004, pe22 (2004).

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