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Sci. STKE, 25 May 2004
Vol. 2004, Issue 234, p. tr3
[DOI: 10.1126/stke.2342004tr3]


Spatial and Temporal Dynamics of Signaling Components Involved in the Control of Chemotaxis in Dictyostelium discoideum

Alan R. Kimmel1, Carole A. Parent2, and Nancy R. Gough3*

1 Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
2 Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
3 Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, Washington, DC 20005, USA.

Abstract: This animation shows the redistribution of several proteins during the chemotactic response of the single-celled organism Dictyostelium discoideum to the chemoattractant cAMP. Much like neutrophils, this organism is able to sense and move toward very shallow gradients of chemoattractant. Mutant strains carrying mutations in genes encoding various signaling components are available and, thus, D. discoideum serves as a model organism for the study of the cellular mechanisms that control chemotaxis and amplification of a signaling gradient across a single cell. The animation would be useful in depicting the dynamic nature of signal transduction, the ability of cells to polarize to allow for directional movement, and the spatial and temporal changes in the activity of specific proteins that accompany chemotactic responses.

*Corresponding author. E-mail: ngough{at}

Citation: A. R. Kimmel, C. A. Parent, N. R. Gough, Spatial and Temporal Dynamics of Signaling Components Involved in the Control of Chemotaxis in Dictyostelium discoideum. Sci. STKE 2004, tr3 (2004).

Nonadaptive Regulation of ERK2 in Dictyostelium: Implications for Mechanisms of cAMP Relay.
J. A. Brzostowski and A. R. Kimmel (2006)
Mol. Biol. Cell 17, 4220-4227
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