Sci. STKE, 25 May 2004
STRUCTURAL BIOLOGY Similar but Not the Same
Resistin and adiponectin are two serum proteins secreted by adipocytes. Adiponectin exists in low- and high-molecular-weight forms (LMW and HMW), and the relative amount of the HMW species correlates with systemic responsiveness to insulin and with thiazolidinedione-induced improvement in animal models of obesity-associated insulin resistance. Patel et al. describe the crystal structure of resistin, which bears no sequence similarity to adiponectin, yet also exists in a small form consisting of three monomers intertwined via a coiled coil and in a larger hexamer formed by the tail-to-tail association of two trimers. A further intriguing similarity is that the smaller, trimeric form of resistin can act as a potent antagonist of insulin effects on rat liver.
Citation: Similar but Not the Same. Sci. STKE 2004, tw190 (2004).
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