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Sci. STKE, 1 June 2004
Vol. 2004, Issue 235, p. pe24
[DOI: 10.1126/stke.2352004pe24]

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From Cell Death to Neuronal Regeneration, Effects of the p75 Neurotrophin Receptor Depend on Interactions with Partner Subunits

Christine Bandtlow1 and Georg Dechant2*

1Institute for Medical Chemistry and Biochemistry, Division of Neurobiochemistry, Innsbruck Medical University, 6020 Innsbruck, Austria.
2Institute for Neuroscience, Innsbruck Medical University, 6020 Innsbruck, Austria.

Summary: In the adult mammalian central nervous system (CNS), growth of neuronal fibers is actively inhibited by myelin. The proteins myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgP), and Nogo-66 have been identified as inhibitory components present in CNS myelin. All three proteins exert their inhibitory activity by binding to a neuronal receptor complex containing the Nogo-66 receptor (NgR) and the neurotrophin (NT) receptor p75NTR. In their recent publication, Mi et al. identify the novel protein Lingo-1 as an interactor of p75NTR and NgR. The Lingo-1-NgR-p75NTR complex is shown to confer the inhibitory effects on nerve cell regeneration of Nogo-66, OMgP, and MAG by activating the small guanosine triphosphatase (GTPase) RhoA. Together with the recent finding that p75NTR interacts with the transmembrane protein sortilin to form a different receptor complex with cell death-promoting activity, the results of Mi et al. indicate that p75NTR exerts its diverse cellular functions by associating with function-specific co-receptors.

*Corresponding author. E-mail: georg.dechant{at}uibk.ac.at

Citation: C. Bandtlow, G. Dechant, From Cell Death to Neuronal Regeneration, Effects of the p75 Neurotrophin Receptor Depend on Interactions with Partner Subunits. Sci. STKE 2004, pe24 (2004).

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