Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 8 June 2004
Vol. 2004, Issue 236, p. tw206
[DOI: 10.1126/stke.2362004tw206]


AUTOPHAGY Cell Death by Another Name

Autophagy is a process in which cells digest their own organelles and proteins in response to nutritional starvation. Yu et al. describe a form of cell death that bears similarities to autophagy. Unlike apoptosis, which depends on activation of proteases in the caspase family, autophagic cell death in a mouse cell line was actually inhibited by caspase-8. Inhibition of expression of two genes known to function in autophagy, ATG7 and beclin 1, reduced cell death caused by inhibition of caspase-8. These findings could impact strategies for combating unwanted apoptosis that use caspase inhibitors to prevent cell death.

L. Yu, A. Alva, H. Su, P. Dutt, E. Freundt, S. Welsh, E. H. Baehrecke, M. J. Lenardo, Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304, 1500-1502 (2004). [Abstract] [Full Text]

Citation: Cell Death by Another Name. Sci. STKE 2004, tw206 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882