Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 8 June 2004
Vol. 2004, Issue 236, p. tw208
[DOI: 10.1126/stke.2362004tw208]


CIRCADIAN RHYTHMS Many Ways to Make a Circadian Oscillator

Circadian pacemakers keep cyanobacteria and eukaryotes on a 24-hour cycle that is synchronized with the environment. In Drosophila, a cryptochrome (CRY) is the primary circadian photoreceptor. It interacts with the transcription factors PERIOD (PER) and TIMELESS (TIM) that are involved in regulation of clock genes. However, the molecular mechanism of entrainment has been unclear. Busza et al. show that CRY binding to TIM is light-dependent in flies. The interaction is transient, but it commits TIM to proteosomal degradation. In CRY, the photolyase homology domain is involved in light detection and phototransduction, whereas the C-terminal domain regulates CRY stability and the CRY-TIM interaction. These results contrast with the functions of Arabidopsis CRY domains.

A. Busza, M. Emery-Le, M. Rosbash, P. Emery, Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science 304, 1503-1506 (2004). [Abstract] [Full Text]

Citation: Many Ways to Make a Circadian Oscillator. Sci. STKE 2004, tw208 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882