Sci. STKE, 22 June 2004
LEARNING AND MEMORY PolyADP-ribosylation and Long-Term Memory
What are the molecular mechanisms underlying the requirement for protein synthesis in learning? Cohen-Armon et al. found that polyADP-ribose polymerase-1 was activated during formation of long-term memories in the sea slug Aplysia. Activation occurred in response to repeated serotonin application in isolated pleural-pedal ganglia, as well as during long-term sensitization of a withdrawal reflex and operant conditioning of feeding behavior. Inhibition of polyADP-ribosylation prevented long-term memory but had no effect on short-term memory. The blockade was effective during training but not during the subsequent consolidation period. The effect on memory could be mediated through histone H1, which the authors showed to be polyADP-ribosylated during long-term memory formation.
M. Cohen-Armon, L. Visochek, A. Katzoff, D. Levitan, A. J. Susswein, R. Klein, M. Valbrun, J. H. Schwartz, Long-term memory requires polyADP-ribosylation. Science 304, 1820-1822 (2004). [Abstract] [Full Text]
Citation: PolyADP-ribosylation and Long-Term Memory. Sci. STKE 2004, tw223 (2004).
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