Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 29 June 2004
Vol. 2004, Issue 239, p. tw235
[DOI: 10.1126/stke.2392004TW235]

EDITORS' CHOICE

TRANSCRIPTION Second Path to Silence

Certain parts of the genome of eukaryotes are packaged into "silent"' heterochromatin. The formation of specific regions of heterochromatin in fission yeast, Arabidopsis, and Drosophila involves the RNA interference machinery. Jia et al. now show that in fission yeast, the binding of either of a pair of transcription factors, Atf1 and Pcr1, in the mating-type region acts in a parallel pathway of heterochromatin nucleation. The analysis links Atf1 and Pcr1, which are members of the ATF/CREB family of proteins involved in cellular response to environmental stresses, to nucleation of constitutive heterochromatin.

S. Jia, K. Noma, S. I. S. Grewal, RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Science 304, 1971-1976 (2004). [Abstract] [Full Text]

Citation: Second Path to Silence. Sci. STKE 2004, tw235 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882