Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 6 July 2004
Vol. 2004, Issue 240, p. tr5
[DOI: 10.1126/stke.2402004tr5]

TEACHING RESOURCES

Canonical Wnt/β-catenin Signaling

Randall T. Moon*

Howard Hughes Medical Institute and Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195 USA.

Abstract: This animation provides an interactive presentation of the Wnt signaling pathway as it may occur in multiple cell types. This animation would be useful in teaching developmental biology, immunology, and cell signaling courses. Activation of Wnt pathways can modulate cell proliferation, cell survival, cell behavior, and cell fate. In the basal, unstimulated state in the absence of ligand, there is a constitutively active kinase, which phosphorylates target proteins, resulting in their degradation. Thus, the presence of the ligand Wnt inactivates the kinase allowing accumulation of β-catenin, which then translocates to the nucleus and acts as a transcriptional regulator.

*Corresponding author. E-mail, rtmoon{at}u.washington.edu

Citation: R. T. Moon, Canonical Wnt/β-catenin Signaling. Sci. STKE 2004, tr5 (2004).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882