Sci. STKE, 6 July 2004
NEUROSCIENCE Phosphatase Provides Context for Axon Guidance
Developing axons encounter an array of signals telling them to go this way or that. In some cases, the same signaling molecule in one context says "this way" and in another context says "that." Chang et al. have now elucidated some of the molecular complexity in these seemingly redundant but contradictory instructions. Identification of a receptor protein tyrosine phosphatase, CLR-1, in Caenorhabditis elegans provides the key. In some contexts, the CLR-1 partnership with netrin, an axon-guidance molecule, results in attraction; in other contexts, it results in repulsion of growing axon tips.
C. Chang, T. W. Yu, C. I. Bargmann, M. Tessier-Lavigne, Negative regulation of netrin-mediated axon attraction by the receptor protein tyrosine phosphatase CLR-1. Science 305, 103-106 (2004). [Abstract] [Full Text]
Citation: Phosphatase Provides Context for Axon Guidance. Sci. STKE 2004, tw245 (2004).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882