Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 13 July 2004
Vol. 2004, Issue 241, p. tw255
[DOI: 10.1126/stke.2412004tw255]

EDITORS' CHOICE

CYTOKINES Modifying Erythropoietin Activity

The cytokine erythropoietin binds to the classic erythropoietin receptor to mediate hematopoiesis and has independent tissue-protective bioactivities. Leist et al. (see the Perspective by Ehrenreich) generated a distinct isoform of erythropoietin that separates its two activities. A carbamoylated derivative did not bind to the classical erythropoietin receptor and lost the hematopoietic capacity of natural erythropoietin. However, the derivative was neuroprotective in animal models of stroke, spinal cord injury, experimental autoimmune encephalomyelitis, and diabetic neuropathy.

M. Leist, P. Ghezzi, G. Grasso, R. Bianchi, P. Villa, M. Fratelli, C. Savino, M. Bianchi, J. Nielsen, J. Gerwien, P. Kallunki, A. K. Larsen, L. Helboe, S. Christensen, L. O. Pedersen, M. Nielsen, L. Torup, T. Sager, A. Sfacteria, S. Erbayraktar, Z. Erbayraktar, N. Gokmen, O. Yilmaz, C. Cerami-Hand, Q. Xie, T. Coleman, A. Cerami, M. Brines, Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305, 239-242 (2004). [Abstract] [Full Text]

H. Ehrenreich, A boost for translational neuroscience. Science 305, 184-185 (2004). [Summary] [Full Text]

Citation: Modifying Erythropoietin Activity. Sci. STKE 2004, tw255 (2004).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882