Sci. STKE, 13 July 2004
CYTOKINES Modifying Erythropoietin Activity
The cytokine erythropoietin binds to the classic erythropoietin receptor to mediate hematopoiesis and has independent tissue-protective bioactivities. Leist et al. (see the Perspective by Ehrenreich) generated a distinct isoform of erythropoietin that separates its two activities. A carbamoylated derivative did not bind to the classical erythropoietin receptor and lost the hematopoietic capacity of natural erythropoietin. However, the derivative was neuroprotective in animal models of stroke, spinal cord injury, experimental autoimmune encephalomyelitis, and diabetic neuropathy.
M. Leist, P. Ghezzi, G. Grasso, R. Bianchi, P. Villa, M. Fratelli, C. Savino, M. Bianchi, J. Nielsen, J. Gerwien, P. Kallunki, A. K. Larsen, L. Helboe, S. Christensen, L. O. Pedersen, M. Nielsen, L. Torup, T. Sager, A. Sfacteria, S. Erbayraktar, Z. Erbayraktar, N. Gokmen, O. Yilmaz, C. Cerami-Hand, Q. Xie, T. Coleman, A. Cerami, M. Brines, Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305, 239-242 (2004). [Abstract] [Full Text]
Citation: Modifying Erythropoietin Activity. Sci. STKE 2004, tw255 (2004).
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