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Sci. STKE, 27 July 2004
Vol. 2004, Issue 243, p. pe39
[DOI: 10.1126/stke.2432004pe39]


Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals

Donald L. Gill1* and Randen L. Patterson2*

1Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
2208 Mueller Laboratory, The Pennsylvania State University, University Park, PA 16802, USA.

Abstract: Receptor-induced Ca2+ signals involve both Ca2+ release from intracellular stores and extracellular Ca2+ entry across the plasma membrane. The channels mediating Ca2+ entry and the mechanisms controlling their function remain largely a mystery. Here we critically assess current views on the Ca2+ entry process and consider certain modifications to the widely held hypothesis that Ca2+ store emptying is the fundamental trigger for receptor-induced Ca2+ entry channels. Under physiological conditions, receptor-induced store depletion may be quite limited. A number of distinct channel activities appear to mediate receptor-induced Ca2+ entry, and their activation is observed to occur through quite diverse coupling processes.

*Corresponding authors. E-mail: dgill{at} (D.L.G); runkinatiaaar{at} (R.L.P.)

Citation: D. L. Gill, R. L. Patterson, Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals. Sci. STKE 2004, pe39 (2004).

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