Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 27 July 2004
Vol. 2004, Issue 243, p. tw275
[DOI: 10.1126/stke.2432004tw275]

EDITORS' CHOICE

NEUROSCIENCE Epilepsy and Dendritic Ion Channels

Little is known about the changes in ion channel function in the neuronal membrane after a region of the brain has become epileptic. Bernard et al. (see the Perspective by Staley) show that the electrical properties of hippocampal pyramidal cell dendrites are altered in a rat model of temporal lobe epilepsy. Back-propagation of dendritic action potentials is enhanced in these animals because of a loss of A-type K+ channel function. This change appears ultimately to alter the input-output characteristics of the dendrites that enhance excitability and susceptibility to seizures.

C. Bernard, A. Anderson, A. Becker, N. P. Poolos, H. Beck, D. Johnston, Acquired dendritic channelopathy in temporal lobe epilepsy. Science 305, 532-535 (2004). [Abstract] [Full Text]

K. Staley, Epileptic neurons go wireless. Science 305, 482-483 (2004). [Summary] [Full Text]

Citation: Epilepsy and Dendritic Ion Channels. Sci. STKE 2004, tw275 (2004).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882