Sci. STKE, 27 July 2004
NEUROSCIENCE Epilepsy and Dendritic Ion Channels
Little is known about the changes in ion channel function in the neuronal membrane after a region of the brain has become epileptic. Bernard et al. (see the Perspective by Staley) show that the electrical properties of hippocampal pyramidal cell dendrites are altered in a rat model of temporal lobe epilepsy. Back-propagation of dendritic action potentials is enhanced in these animals because of a loss of A-type K+ channel function. This change appears ultimately to alter the input-output characteristics of the dendrites that enhance excitability and susceptibility to seizures.
Citation: Epilepsy and Dendritic Ion Channels. Sci. STKE 2004, tw275 (2004).
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