Sci. STKE, 17 August 2004
NEUROSCIENCE Protecting Damaged Axons
Degeneration of axons that have been severed from their neuronal cell bodies can follow a specific course of progressive fragmentation called Wallerian degeneration. Various neurodegenerative diseases are also characterized by axonal degeneration. Araki et al. (see the Perspective by Bedalov and Simon) provide new insight into what directs the course of organized axonal degeneration. Analysis of a fusion protein resulting from a mutation that slows axon degeneration implicates the nicotinamide adenine dinucleotide biosynthetic pathway in this type of axonal degeneration.
Citation: Protecting Damaged Axons. Sci. STKE 2004, tw297 (2004).
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