Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 24 August 2004
Vol. 2004, Issue 247, p. tw305
[DOI: 10.1126/stke.2472004tw305]

EDITORS' CHOICE

IMMUNOLOGY The Path to Maturity

To efficiently activate T cell immunity, dendritic cells (DCs) must undergo a program of maturation steps to allow them to become proficient at taking up antigen and activating T cells. West et al. observe that DC maturation includes a previously unappreciated early acute response after activation via Toll-like receptors. A transient phase of endocytosis that involved redeployment of the actin cytoskeleton ultimately led to increased antigen presentation. Benvenuti et al. show that at a later stage of maturation, DCs use the guanosine triphosphatases Rac1 and Rac2 to extend the cytoskeleton to form critical membrane contacts with activating T cells. The two studies reveal a dynamic and highly regulated orchestration of actin cytoskeleton deployment at distinct stages of the DC activation program.

M. A. West, R. P. A. Wallin, S. P. Matthews, H. G. Svensson, R. Zaru, H.-G. Ljunggren, A. R. Prescott, C. Watts, Enhanced dendritic cell antigen capture via Toll-like receptor-induced actin remodeling. Science 305, 1153-1157 (2004). [Abstract] [Full Text]

F. Benvenuti, S. Hugues, M. Walmsley, S. Ruf, L. Fetler, M. Popoff, V. L. J. Tybulewicz, S. Amigorena, Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science 305, 1150-1153. [Abstract] [Full Text]

Citation: The Path to Maturity. Sci. STKE 2004, tw305 (2004).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882