Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 12 October 2004
Vol. 2004, Issue 254, p. tw369
[DOI: 10.1126/stke.2542004tw369]


METABOLISM A Sophisticated Riboswitch

RNA gene control elements, or "riboswitches," can regulate gene expression in ways that were once thought to be the domain of proteins. Mandal et al. (see the Perspective by Famulok) now show that adjacent RNA motifs cooperatively bind two molecules of glycine in Bacillus subtilis and turn on an operon involved in glycine cleavage. The level of cooperativity per binding site produces a switch that is sensitive to very small changes in glycine concentration. The riboswitch controls genes responsible for shunting the carbon from excess glycine into the citric acid cycle.

M. Mandal, M. Lee, J. E. Barrick, Z. Weinberg, G. M. Emilsson, W. L. Ruzzo, R. R. Breaker, A glycine-dependent riboswitch that uses cooperative binding to control gene expression in bacteria. Science 306, 275-279 (2004). [Abstract] [Full Text]

M. Famulok, RNAs turn on in tandem. Science 306, 233-234 (2004). [Summary] [Full Text]

Citation: A Sophisticated Riboswitch. Sci. STKE 2004, tw369 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882